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Mast cells and histamine-releasing immune cells in your skin gather at the injection location, triggering the classic itch sensation within minutes to hours

10.2337/diabetes.53.1.5 24 HuntD

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The signaling through GLP-1R leads to improved glycemic control and weight management, ultimately resulting in approval of GLP-1 receptor agonist medications for the treatment of T2DM and obesity [1]