In the SURPASS-2 study, Mounjaro 15 mg reduced A1C by 2.3% compared to 1.86% with semaglutide (1 mg) over 40 weeks
The SURMOUNT-1 trial (Jastreboff et al., 2022, New England Journal of Medicine) extended these findings to adults with obesity without diabetes
For semaglutide, that means 0.25 mg weekly
Skeletal muscle is: A major contributor to resting metabolic rate A key site for glucose metabolism Essential for strength, mobility and independence Losing muscle can lower the number of calories your body burns at rest
These injectable therapies are sensitive to temperature and light, and even minor mistakes in handling can reduce their effectiveness
In many cases, patterns such as binge eating, emotional eating, or stress eating can override the medications effects