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N6-methyladenosine (m 6 A) demethylase FTO is significantly upregulated in MPP + -stimulated SK-N-SH cells, which suppresses YTH domain family protein 2 (YTHDF2) expression, promotes m 6 A demethylation of BRCA1-associated protein 1 (BAP1) and enhances BAP1 expression, upregulates p53 expression, and inhibits SLC7A11 transcription, thereby increasing MDA, Fe 2+ , and 4-HNE levels and triggering neuronal ferroptosis
The N-terminus of GPCR is located extracellularly, whereas its C-terminus contains threonine and serine residues that promote the phosphorylation and intracellular signal transduction of downstream substrates via the G protein -subunit in vivo
Sex difference in susceptibility to acetaminophen hepatotoxicity is reversed by buthionine sulfoximine
Free Radical Biology and Medicine, 125 , 1524
Appl Biochem Biotechnol 166:402413
2006 Sep;449(3):34857
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