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The substantial weight reduction observed with tirzepatide monotherapy (15-21% body weight in clinical trials) suggests that any perceived benefits likely reflect tirzepatide's pharmacological effects rather than synergistic action

This is particularly interesting result, as a genetic variant near FSHR (rs1405966) has already been suggestively associated with TgAb levels in females from Croatian general population 31 , thus providing solid evidence of the enrollment of this gene with thyroid antibody development

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To better understand the cellular uptake mechanisms of targeted nanocarriers we investigated the effects of free ligands, metabolic and endocytic inhibitors, and the modification of brain endothelial surface charge