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We showed that mice fed a high-fat diet (HFD) for 12 weeks developed hepatic steatosis and liver injuries, which were associated with not only TNF overproduction but also hepatic glutathione dysregulation, characterized by GSH reduction and GSSG elevation
The amide group is acetamide (ethanamide)
Genetic polymorphisms of glutathione S -transferase genes GSTM1 GSTT1 and risk of hepatocellular carcinoma
This is the core challenge with both of these molecules
1d, Methods)
Would it exacerbate oxidative stress, leading to more severe damage
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