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As early as 1969, clinical studies conducted in homocystinuric children revealed the importance of severe hyperhomocysteinemia in premature development of atherosclerosis and thromboembolism (McCully, 1983)
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The most common side effect experienced by individuals is mild discomfort at the injection site, which is temporary and resolves quickly
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ROS were proven to deplete the content of antioxidants in the skin
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