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The tripeptide modulates over 4,000 human genes (31.2% of the genome) and plasma levels decline from approximately 200 ng/mL at age 20 to less than half by age 60 (Pickart & Margolina, 2018)

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Without human trials, clinicians cannot reliably determine appropriate dosing, long-term risks or whether benefits outweigh risks

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Hypersensitivity is very rare, but resuscitation facilities should be available when administering injections