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This paradoxical vulnerability indicates that GSH-dependent redox homeostasis, while essential for normal cellular function, can become a critical liability in cancer cells with dysregulated GSH metabolism
The results further confirmed the role of the GH axis in the sex dimorphism of CRY/ male mice ( In addition, studies have confirmed that the disruption of the circadian clock system affects the release of GH and GH-mediated signal pathways
A large number of studies have concluded that the decreased intracellular pH of endosomes and lysosomes in tumor cells may assist in metastasis by activating proteases [42, 48]
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