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Symptoms of Varicose Veins Visible, bulging veins, often blue or purple Aching or heavy feeling in the legs Swelling in the ankles and feet Burning, throbbing, muscle cramping, and swelling in the lower legs Itching around the veins Pain that worsens after standing or sitting for long periods In some cases, varicose veins can lead to complications, such as blood clots or skin ulcers

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What happened: The 503B Bulks List proposal On April 30, 2026, the FDA announced it is proposing to exclude semaglutide, tirzepatide, and liraglutide from the 503B Bulk Drug Substances List