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Quinolinic acid (quinurenine metabolites) is a precursor of nicotinamide adenine dinucleotide (NAD) that has neurotoxic properties through its binding to the postsynaptic N-methyl-D-aspartate (NMDA) receptor, followed by a sustained influx of Ca2+ leading to increased oxidative and nitrosative stress (197, 198)
Zhang, Y., Zhang, H., Ghosh, D., & Williams, R
Yes, daily glutathione supplementation is generally considered safe for most adults when taken at recommended doses (250 mg to 1,000 mg per day)
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