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Interestingly, patients receiving semaglutide QW were more likely to be part of the commercial claim subgroup versus the Medicare claim subgroup, which suggests that the major differences in baseline characteristics observed were primarily driven by the commercial/Medicare ratio
Morimoto T, et al
The extended duration means that instead of a brief post-meal signal, the medication provides continuous GLP1 receptor activation throughout the week, producing the persistent appetite suppression and significant weight loss seen in clinical trials
References The Bottom Line While these medications can be safely combined, increased fertility potential and absorption issues from nausea make backup contraception essential for reliable pregnancy prevention
It may appeal to patients looking for a well-established option with broader name recognition and a longer track record in UK clinical practice
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