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Presented for research literature review only Borab ZM et al

SUA is taken up by OAT1/OAT3 into tubular cell, then intracellular UA is excreted by NPT4 into the urinary lumen (Mller and Sheikh, 1982

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After that, a once per month dose is needed to maintain proper B12 levels

This unanticipated outcome may provide critical clues to the mechanism underlying GEP44-mediated weight loss observed in experiments performed in vivo