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In the context of new drug discovery, particularly for anti-obesity treatments, addressing the cost-effectiveness and accessibility of these innovations is critical for their widespread clinical adoption

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Some studies suggest that the beneficial effects of GLP-1RAs can be dampened by the deleterious effects of long-standing T2DM resulting in the reduced capacity to secrete insulin and diminished incretin effects, resulting in reduced glucose-lowering efficacy of GLP-1RA [89, 90]

Compassionate Use Programs Compassionate use (or expanded access) is a regulatory pathway that allows the use of an investigational drug outside of a clinical trial for patients with a serious or immediately life-threatening condition who have no comparable treatment options