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There is growing body of evidence that GLP-1 RAs demonstrate numerous metabolic benefits in PCOS, including a high effect on prediabetes remission rate, a significant reduction in atherothrombotic markers, and an improvement in lipid profile (2932)

NHSBT has specific deferral periods following gastrointestinal illness that would apply in these circumstances

When comparing metformin and semaglutide, the evidence points in a clear direction for most people who want meaningful weight loss

doi:10.1016/j.jaac.2025.09.025 Morley K, Arunogiri S, Connor JP, et al

Sarcopenia (muscle loss) due to rapid weight loss if measures to preserve muscle are not taken, including regular strength training, staying active, and eating a protein-rich diet

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