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In Eli Lillys Phase 2 trial published in NEJM in 2023, participants on the highest dose (12 mg weekly) lost an average of 24.2% of their body weight over 48 weeks
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Common causes include water retention (especially after dose increases or during hormonal fluctuations), muscle gain offsetting fat loss (particularly in people who are exercising consistently), metabolic adaptation, and changes in dietary habits that may have gradually increased caloric intake
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Between 40 percent and 90 percent of people with RLS have at least one first-degree relative (a parent, sibling, or child) with the condition, according to the Sleep Foundation
A recent 2023 meta-analysis highlighted the potential benefit of L-carnitine supplementation in the treatment of diabetes, showing promising results after analyzing 41 randomized clinical trials
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