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When it binds to receptors in the pituitary gland, which is responsible for synthesizing and secreting HGH, it signals the gland to produce more HGH

Nagashima M, Watanabe T, Terasaki M et al (2011) Native incretins prevent the development of atherosclerotic lesions in apolipoprotein E knockout mice

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This directly complicates patient screening and enrollment, leads to substantially lower overall expected efficacy compared with patients harboring upstream genetic defects (such as POMC deficiency) [56] , and results in a low statistical success rate in large-scale trials

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Dose: The starting dose of Rybelsus is 3 mg once daily and titrates up to 14 mg once daily