When any part of this system is disrupted, oxalate levels can rise abnormally high
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Examination of the GCL from these different organisms suggests that the interplay between the redox-sensitive thiol-switch and dimerization of the plant enzymes occurred later in evolution and may be related to compartmentalization of glutathione synthesis in the chloroplast (Gromes et al., The sub-organellar localization of GCL raises questions about redox regulation of glutathione biosynthesis in plants
(More information) Vitamin E deficiency can be caused by fat malabsorption disorders or by genetic abnormalities that affect vitamin E transport
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Other chemicals, such as acetaminophen, heavy metals, nitrates, and aspartame, might also interfere with glutathione absorption