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This review focuses on recent studies, demonstrating the actions of local IGF-I/IGF-IR signaling in (a) supporting skeletal development and remodeling, (b) cross-talk with other autocrine/paracrine pathways in the bone, (c) mediating cell-cell interactions between various types of skeletal cells, and (d) integration with systemic signals to produce skeletal anabolism
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J Neurosci 18:52255233 Bigford GE, Del Rossi G (2014) Supplemental substances derived from foods as adjunctive therapeutic agents for treatment of neurodegenerative diseases and disorders
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