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The review also noted that decreased GLP-1 secretion may contribute to obesity development, and that exaggerated secretion may be responsible for postprandial reactive hypoglycaemia

Inclusion and exclusion criteria are listed in Table 1

On the contrary, a small study of fewer than 10 obese patients who took berberine three times a day for three months found their average weight loss with berberine was just around 5 pounds

[1] [2] The safety profile of weight loss injections in post-bariatric surgery patients requires special consideration due to the altered gastrointestinal anatomy and physiology created by surgical intervention

It is important to distinguish between medically indicated enzyme replacement therapy, which addresses genuine enzyme deficiency, and supplemental enzymes taken for non-specific digestive symptoms