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The mechanism appears to involve increased serotonin synthesis in substantia nigra (both compacta and reticulata), a regional pattern unlike any existing antidepressant drug, plus potential dopaminergic contributions given the nigrostriatal location

Semaglutide (e.g., Wegovy, Ozempic) : Wegovy : Single-use pens can be stored at room temperature for up to 28 days

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The standard initial loading dose is 1,000 mcg administered intramuscularly (IM) once weekly for 4 weeks

Vitamin B12 (cobalamin) is essential for DNA synthesis, myelin formation, and red blood cell maturation

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