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Neurosci Biobehav Rev 23:11111125 Mercuri NB, Saiardi A, Bonci A, Picetti R, Calabresi P, Bernardi G, Borrelli E (1997) Loss of autoreceptor function in dopaminergic neurons from dopamine D2 receptor deficient mice
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They appear in the distribution-matching pattern when the offending substance comes into contact with the skin, making location a useful diagnostic clue
A newer oral option is also now licensed
