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In colorectal cancer, the combination of one-carbon metabolism inhibitors with anti-EGFR antibodies (e.g., cetuximab) has been proven to effectively suppress the growth of tumors with high ERK-ILF3 expression (115)
doi: 10.1186/1471-2105-9-559 49 JiangPGuSPanDFuJSahuAHuXet al
The theoretical synergies described are based on component mechanisms rather than validated combination studies
Most optimization happens in the first 2-3 weeks of this phase
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