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An abundant TCA metabolite is succinate, which, like lactate, appears in the extracellular milieu, where it can be taken up by surrounding cells

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Furthermore, accelerated glucose depletion alleviates T cell suppression and promotes the repolarization of immunosuppressive M2 macrophages towards antitumor M1 phenotypes, ultimately reversing tumor immunosuppression [75, 76]

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Vasculitis and Connective Tissue Disorders Inflammation of blood vessels (vasculitis) can cause fragile vessels and skin changes, leading to bruising or purpura