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Continuous use year-round at maintenance doses (0.5mg twice weekly) has been reported in research contexts for up to 24 months without tolerance development or cumulative adverse events beyond those seen in short-term protocols

Liao C, et al

The injectable versus oral peptide comparison provides additional context

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How AOD-9604 Works: Mechanism and Research Evidence AOD-9604 was designed to copy the fat-metabolism end of human growth hormone without the rest of growth hormone's effects

Side-effect profiles are similar overall, with slightly different GI symptom patterns