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This hormone plays a critical role in regulating appetite and blood sugar

That figure is not unique to GLP-1 medications, some lean tissue loss accompanies most significant weight loss, but the pace and scale of GLP-1-driven weight loss makes the risk more acute

PubMed research supports that insulin resistance is a core factor in various health issues beyond diabetes, including fatty liver, cognitive impairment, and cardiovascular disease (Springer)

Some patients do well with slower titration or the lowest effective dose

Long-term safety beyond 5 years is still under study

Human studies in this area are limited by small sample size and often nonrandomized character