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225 Occasionally, statins may cause an elevation of the liver enzymes aspartate aminotransferase (AST) and alanine aminotransferase (ALT)

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A phase 2 trial published in the New England Journal of Medicine showed average weight loss of over 24% at 48 weeks, and the first phase 3 results in December 2025 suggested that average weight loss could be around 28 to 29%

Verrotti A, Trotta D, Morgese G, Chiarelli F: Valproate-induced hyperammonemic encephalopathy

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That warning stems from animal studies that suggested a possible increased risk, though more recent research published in 2025 suggests the same risk may not apply to humans