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7 d In a prespecified analysis of primary-outcome events occurring through Week 156 (3 years), the absolute risk reduction was 2%, and the number needed to treat to prevent one event in this population was 50 persons (95% CI: 31-125)

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[23] [24] For individuals with stress-related cortisol dysregulation without overt pathology, management focuses on lifestyle interventions : stress reduction techniques (such as cognitive behavioural therapy, mindfulness, and relaxation exercises), regular physical activity, adequate sleep, and a balanced diet

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