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Practical takeaway: Most human users report noticeable appetite suppression during the first 3-7 days of loading, consistent with the animal data showing rapid onset followed by tolerance

Several investigations have associated the polymorphic polyglutamine repeats in the NTD with Kennedy's Disease, also known as spinobulbar muscular atrophy, a progressive neurodegenerative condition 105,106,107

Weight changes are gradual and may continue over several months

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