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They found that semaglutide users in the STEP 1, 2 and 3 trials were less likely to shift to a more severe category of PHQ-9 depression (OR = 0.63

[124] conducted a double-blind, practical trial in which participants were randomly assigned to receive exenatide or placebo to measure changes in carotid plaque volume and composition at 9 and 18 months of treatment, and found no difference in mean change in plaque volume in the exenatide group compared with placebo

The 28-day rule is based on contamination risk, not chemical stability, which persists beyond this period