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They work by mimicking the action of naturally occurring GLP-1, an incretin hormone released from the intestine in response to food intake
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In patients with obesity, significant weight reduction achieved with GLP-1 therapy has been associated with improvements in sex hormone-binding globulin (SHBG) levels, reductions in free testosterone in women with hyperandrogenism, and normalization of menstrual cycles in some individuals with polycystic ovary syndrome (PCOS)
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The same module found a 20% increase in metoprolol Cmax (unchanged AUC), also deemed not clinically significant [1]
Week 3 to 4: Nausea typically eases
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