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Inhibition of the immunoproteasome LMP2 ameliorates ischemia/hypoxia-induced bloodbrain barrier injury through the Wnt/-catenin signalling pathway
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Specifically, simulations suggest that blood Cys and GSH are reduced by 68.7% and 74.1% respectively, whereas cytosolic Cys and GSH are reduced by 81.2% and 64.6% respectively
GSTs bind electrophilic compounds (which are inherently reactive and can damage DNA, proteins, and lipids) and attach glutathione to them, neutralizing their reactivity and making them water-soluble for excretion