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62 Despite these indications of tumor sensitivity to insulin, it is not clear to which extent the modulation of insulin and IGF-1 levels is able to influence the proliferation of progressive cancers that have become self-sufficient in growth and metabolic signals as illustrated for example by: (i) expression of insulin-independent glucose transporter isoforms

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Patients with diabetes or prediabetes may require adjustments to glucose-lowering medications when using both drugs concurrently

PMID: 8138058