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Its cell-penetrating properties allow it to enter cells without transfection or vector delivery, where it directly engages the p53 TAD2 domain to disrupt the FOXO4-p53 complex
Clinical significance is unknown, but caution is reasonable
The Bottom Line GHK-Cu is a naturally occurring copper tripeptide that stimulates collagen synthesis at picomolar concentrations, modulates over 4,000 genes, and has shown measurable wrinkle reduction and collagen improvement in clinical studies