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Acidosis is due to reduced feedback inhibition of -glutamyl cysteine synthetase in the gamma-glutamyl cycle, which ultimately leads to overproduction and accumulation of 5-oxoproline
Evidence suggests that epigenetic mechanisms, including DNA methylation, histone modification, and microRNAs, impact the endotheliums ability to respond to blood flow (78)
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J Allergy Clin Immunol 124 : 990996
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