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This approach helps minimize common gastrointestinal side effects such as nausea, vomiting, and diarrhea, which are more likely when starting at higher doses

Eating smaller, more frequent meals rather than large ones reduces the nausea associated with gastric emptying changes

As biologics, they require advanced manufacturing technologies, prompting targeted capital investments beyond conventional OSD infrastructure

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While insurers frequently cover these drugs for diabetes, weight-loss-only prescriptions may face denials

In vitro experiments have shown that GSH deficiency induced by either the siRNA approach or pharmacological inhibition of the GCL rate-limiting enzyme decreases GSH biosynthesis and escalates oxidative stress in cultured hepatocytes