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Kapaa A, Szlendak M, Motacka E

In contrast, an increased spermidine/spermine ratio (resulting from a spermine synthase gene mutation in mice) was linked to increased anxiety, downregulated mitochondrial oxidative phosphorylation and ribosomal protein synthesis in the cerebral cortex, as well as impaired mitochondrial bioenergetics in isolated primary fibroblasts (Akinyele et al

In AKI, mitochondrial energy metabolic reprogramming plays a key role in disease pathogenesis

Modulation of diet-induced mechanical allodynia by metabolic parameters and inflammation

Administration routes Different peptides favor different administration routes, and the choice can significantly affect both bioavailability and the distribution of effects throughout the body

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