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To understand the dynamics of this interplay in T1DM, one must go back to the relation between portal insulin and GHR expression on hepatocytes, which was so cleverly addressed by Leung et al
Some report that lower doses, including approaches like low-dose semaglutide or semaglutide microdosing, feel easier to tolerate and less disruptive to daily routines, particularly early in treatment
Starting low and increasing provides more signal
Experts said their model was plausible but, data so far has come from clinical trials and it remains unclear what will happen in the real-world use of GLP-1 medications
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