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In contrast, the passive diffusion process of B 12 absorption normally a very small portion of total absorption of the vitamin from food consumption may exceed the haptocorrin- and IF-mediated absorption when oral doses of B 12 are very large, with roughly 1% efficiency

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it's nuanced and rooted in understanding how different hormonal axes in the body communicate

Vitamin B6 is essential for the synthesis of neurotransmitters and the transformation of food into energy