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In mouse models, increasing ovarian NAD + levels activates SIRT1 signaling, promotes mitochondrial biogenesis, improves energy metabolism, and enhances oocyte quality [303]
Taking these results together, oxidative stress apparently contributes to the pathological changes observed in SNHL
Acetyl-L-carnitine-mediated neuroprotection during hypoxia is attributed to ERK1/2-Nrf2-regulated mitochondrial biosynthesis