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2 Adverse events in PIONEER 4 (a head-to-head trial vs liraglutide 1.8 mg) 2 Comparator AE rates are not an adequate basis for comparison of safety between products 1 Because clinical trials are conducted under widely varying conditions, AE rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice 1 a Data are n (%)

Before we get too far, lets acknowledge that GLP-1 medications are a major advancement in obesity treatment

10.1007/s12011-020-02515-y 71 WangX.HanY.ChenF.WangM.XiaoY.WangH.et al (2022)

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Metabolic changes affecting nerve function

Clinicians should screen for depression and anxiety disorders, which frequently coexist with obesity and may benefit from specific treatment