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Additionally, the short intraocular half-life of most ferroptosis modulators, which is less than 1.5 hours in the aqueous humor, necessitates frequent administration, further reducing patient compliance (160)
While the brain uptake of GLP-1RAs has been extensively studied in animals, the translation of these findings to human clinical outcomes remains uncertain [126]
A meta-analysis of 12 randomized controlled trials (n = 17,996) further confirmed these renoprotective effects, with agents structurally closer to endogenous human GLP-1, such as semaglutide, showing the strongest benefit (RR = 0.78, 95% CI: 0.710.85) ( 3.4 Hepatic protection In clinical practice, semaglutide has demonstrated notable efficacy in resolving NASH without aggravating hepatic fibrosis
