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Biochemically these individuals manifest with elevated levels of polyols, particularly ribitol, D-arabitol, in body fluids and in the brain
Antioxid Redox Signal 12(7):819827
"Regulation of cellular glutathione"
Kidney Int 65:259265 Kwakernaak AJ, Zelle DM, Bakker SJL, Navis G (2013) Central body fat distribution associates with unfavorable renal hemodynamics independent of body mass index
As a result, the broader clinical applicability of these findings requires further exploration through larger-scale studies
A preparation that appears 98% pure by HPLC may contain a significant fraction of non-native disulfide isomers that bind IGF-1R poorly
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