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High-bioavailability drugs with wide therapeutic windows Drugs like metformin, statins (most are highly absorbed across a wide pH range), and most SSRIs have wide enough therapeutic windows that a modest delay in Tmax is unlikely to produce clinical consequences
It hampers nutrient and oxygen diffusion, decreases capillary flexibility, disrupts pericyte-endothelial communication, traps vascular cells leading to apoptosis, and promotes a self-reinforcing cycle of extracellular matrix buildup driven by TGF-/CTGF (20, 21)
Options include a 24-hour liquid-only diet before surgery, point-of-care gastric ultrasound, modification of anesthetic technique, and elective delay when risk is temporary and expected to improve
Withdraw the needle and release the skin fold
You should avoid the inner thigh or the area too close to the knee, as these spots have less fatty tissue and may be more sensitive
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