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Endocrinology 150 , 11741181 (2009)

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For most people, gastrointestinal side effects are at their worst in the first two to four weeks of each new dose level and improve significantly as the body adjusts

GLP-1RAs alleviate vascular aging under chronic stress via increasing adiponectin (APN) levels and inhibiting aortic MMP-9 and MMP-2 expression in ApoE -/- mice [96, 149]

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