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Tapering or Stopping Tirzepatide In some cases, your healthcare provider may advise you to taper off tirzepatide before starting semaglutide, to prevent any overlap or complications

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When peptides influence body composition or insulin sensitivity, they may interact negatively with weight loss therapy plans or nutritional supplements

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This is an observational study, and we cannot use these findings to justify any clinical practice changes, which will require randomized clinical trials, but our study supports future randomized clinical trials, Xu said