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With retatrutide, the curve continues descending through this entire period, driven in part by the ongoing glucagon receptor activation that other medications lack

Early results are promising, but complete data takes time to accumulate

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Routes of Administration Subcutaneous injection (community protocol): Community sources describe the abdomen, love handles, and thighs areas with subcutaneous fat as the typical injection sites, at a volume of approximately 0.1 mL using a 29-31 gauge insulin syringe

Notably, the risk appeared higher in trials studying weight loss indications, with higher doses, and with longer duration of treatment