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The renal clearance is limited by the large albumin-bound complex, with proteolytic degradation being the primary elimination pathway
After the last dose of oral semaglutide, PK samples were collected for 504 and 24 h for semaglutide and SNAC assessments, respectively
Nevertheless, long-acting agents such as weekly semaglutide remain clinically relevant because of their prolonged half-lives and continued gastrointestinal effects in some patients
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