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Cannabis, in particular, is one of the oldest recreational substances with a long history of use, while MDMA has been extensively studied for its recreational effects since its emergence several decades ago

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This creates a regional pattern that does not resemble the results obtained with any other serotonergic drug using this method. Why This Matters This nigrostriatal focus is mechanistically intriguing because these regions are heavily involved in motor control, reward processing, and motivation

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BDNF plays a critical role in learning, memory formation, and overall brain adaptability