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Several studies revealed that GLP-1RAs relieve myocardial damage and glucose toxicity by promoting autophagy, which is associated with decreasing mTOR phosphorylation and increasing AMPK phosphorylation [88]
NICE guidance for type 2 diabetes management (NG28) recommends GLP-1 receptor agonists as part of dual or triple therapy when specific criteria are met
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As such, any retail availability for Retatrutide is typically restricted to research-grade materials intended for laboratory use, where purity and supplier verification are essential for study validity.
