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Although direct clinical evidence of systemic NAD(P) depletion during GLP-1RA therapy is lacking, experimental and observational studies suggest that NAD turnover and micronutrient status can be altered in obesity and inflammatory states [83, 85], supporting the biological plausibility of substrate-sensitive vulnerability

There was no clear association between GLP-1 RA use and improvement in cognitive outcomes

doi: 10.3390/biomedicines13092190 91 ChisariMGEspositoMAllocaSVarrialeBSalernoMRasoGMet al

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These therapies offer a new horizon for patients who have struggled with traditional weight loss methods

Its ability to tackle obesity, insulin resistance, and metabolic dysfunction is groundbreaking